ISSN:
1432-0428
Keywords:
Streptozotocin (low dose)
;
prazosin
;
vasoactive amine antagonists
;
insulitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pancreatic islet inflammation and subsequent diabetes was induced by multiple low doses of streptozotocin in male C57 Bl/6J mice. The development of hyperglycaemia was almost completely prevented by treating the animals with the α1-adrenoceptor antagonist prazosin (20 mg·kg−1. day−1) as well as by the vasoactive amine antagonists methysergide (50 mg·kg−1·day−1), disodium cromoglycate (100mg·kg−1·day−1), pizotifen (5 mg·kg−1·day−1) or cyproheptadine (20 mg·kg−1·day−1). Treatment with vasoactive amine antagonists largely inhibited infiltration of pancreatic islets by L3T4+-lymphocytes and to a lesser extent by Lyt2+-cells. The infiltration of macrophages was not affected except after pizotifen treatment. These results indicate that α1-adrenoceptor activation is required for disease development and that vasoactive amine release is a prerequisite for lymphocytic insulitis but not for macrophage infiltration of islets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00505187
