ISSN:
1432-0738
Keywords:
F344 rats
;
B6C3F1 mice
;
Toxicology
;
1,2-dibromo-3-chloropropane
;
1,2-dibromoethane
;
Respiratory tract
;
Nasal epithelium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Seventy F344 rats and 144 B6C3F1 mice were subdivided into seven groups. Three groups were each exposed via inhalation to 1, 5, or 25 ppm of 1,2-dibromo-3-chloropropane (DBCP) for 6 h per day, 5 days per week for 13 weeks. Three additional groups were each similarly exposed to 3, 15, or 75 ppm of 1,2-Dibromoethane (EDB). The remaining group was exposed to room air under the same conditions. At 13 weeks, rats and mice showed severe necrosis and atrophy of the olfactory epithelium in the nasal cavity after inhalation of 5 or 25 ppm DBCP and 75 ppm EDB. Lower concentrations induced squamous cell metaplasia, hyperplasia and cytomegaly of the epithelium of the respiratory nasal turbinals. Squamous metaplasia, hyperplasia and cytomegaly of the epithelium was also seen in larynx, trachea, bronchi and bronchioles. Other compound related toxic lesions in rats were seen in the liver, kidney and testes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310439
