ISSN:
1432-1912
Keywords:
Ethanol
;
Blood-brain barrier
;
Carrier transport
;
Tyrosine
;
Tryptophan
;
5-Hydroxytryptophan
;
α-Methyldopa
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Ethanol 2 g kg−1 i.p. to rat increased the concentrations in the brain of administered large neutral amino acids (tyrosine, tryptophan, 5-hydroxytryptophan and α-methyldopa). We have previously found a similar effect of ethanol on administered l-Dopa, resulting in increased brain/plasma ratios of dopa. Since large neutral amino acids are known to compete with each other for the carrier-mediated transport into the brain we suggest that the increased concentrations of the administered amino acids in the brain are at least partly the consequence of the ethanol-induced decrease in plasma amino acids observed previously.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00498430
