ISSN:
1432-1912
Keywords:
Digitoxose
;
Metabolism
;
Liver Enzymes
;
Excretion
;
Rat
;
Digitoxose
;
Stoffwechsel
;
Leberenzyme
;
Ausscheidung
;
Ratte
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An NAD dependent “digitoxose dehydrogenase” has been demonstrated in extracts from rat liver; the Km values of this enzyme have been determined. Polyacrylamide disc gel electrophoresis shows that there are at least four different proteins capable of oxidizing digitoxose. After i.p. injections of digitoxose into normal rats 53.3% of the deoxysugar injected are excreted in the animals' urine as digitoxose, digitoxonic acid or digitoxonic-γ-lactone. The corresponding figure for adrenalectomized rats instead of normal animals is 68.3%-“Digitoxose dehydrogenase” of the rat liver seems to be a constitutive enzyme. The increased excretion of digitoxonic-lactone following adrenalectomy can be interpreted as a “permissive effect” of the adrenal hormones upon digitoxose metabolism beyond the stage of the digitoxonic lactone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997147
