ISSN:
1432-2072
Keywords:
Moclobemide
;
Pharmacokinetics
;
Interaction
;
Food effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC↑) and on systemic clearance (AUC↓) balance each other out.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02246232