ISSN:
1432-2072
Keywords:
Rhesus monkeys
;
Etonitazene HCl
;
Etonitazene concentration
;
Etonitazene reinforcement
;
Fixed-ratio schedules
;
Etonitazene drinking
;
Oral self-administration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426626
