ISSN:
1432-2013
Keywords:
FMRFamide
;
single-channel
;
Na+ ions
;
depolarisation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This report presents evidence that the molluscan neuropeptide FMRFamide can directly activate a ligand-gated ion channel in Helix neurones. Using the patch-clamp technique we have observed unitary currents activated by the application of FMRFamide onto outside-out patches. As for the whole-cell response, Na+ ions are the main charge carriers. We conclude that FMRFamide may act as a fast depolarising neurotransmitter in the Helix nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00382698