ISSN:
1432-2013
Keywords:
Key words Anaesthesia
;
Chloralose
;
Ketamine
;
Sodium excretion
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Studies on the mechanisms underlying Na balance in anaesthetized rats are complicated by the fact that the most frequently used barbiturate anaesthetics attenuate or abolish this phenomenon. In the present study we show that a combination of nonbarbiturate anaesthetics: chloralose (140 mg/kg i.v.) and ketamine (30 mg/kg i.m.), preserve the ability of rats to excrete intragastrically applied NaCl loads dose dependently. Thus rats anaesthetized with this regime excreted 86–102% of in- tragastrically applied NaCl whereas rats anaesthetiz- ed with thiobutabarbitone sodium (Inactin) excreted only 20–28%. We conclude that chloralose/ketamine anaesthesia is suitable for studies on Na balance mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004240050220
