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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 411-414 
    Details
    ISSN: 1432-1041
    Keywords: SUN 1165 ; renal failure ; antiarrhythmic agent ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new Class I antiarrhythmic agent, SUN 1165, has been studied in 32 patients with varying degrees of renal impairment following a single oral dose of 50 mg. The apparent volume of distribution at steady state was 1.48 1 · kg−1, the absorption rate constant was 2.2 h−1, and plasma protein binding was 26.8% in subjects with normal renal function. These variables were not altered with renal impairment. More than 60% of SUN 1165 given orally was excreted unchanged via the kidney, both by tubular secretion and glomerular filtration. The elimination rate constant, the apparent total body clearance and the apparent renal clearance were linearly correlated with the endogenous creatinine clearance. The half-time of elimination was 3.4 h in normal subjects and it was prolonged to 23.7 h in severe renal failure (creatinine clearance below 20 ml · min−1 · 1.48 m−2). Dosage adjustment of SUN 1165 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265853
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  • 2
    Electronic Resource
    Electronic Resource
    Renal effects of manidipine hydrochloride (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: Manidipine ; Essential hypertension ; renal function ; glomerular hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The renal effects of manidipine hydrochloride were investigated in ten hospitalised patients with mild-to-moderate essential hypertension. After a one-week placebo period, manidipine was given for 1 week in a dose rising from 5 mg to 10 mg or 20 mg daily to normalise the mean blood pressure measured after 2 h. Blood pressure had decreased from 171/101 to 147/86 mm Hg at the end of manidipine treatment. The pulse rate was unaltered. Renal vascular resistance decreased from 1.90 to 1.33 dyn · s · cm−5/1.48 m2 × 104, and renal blood flow and glomerular filtration rate increased from 522 to 662 ml · min−1 · 1.48 m−2 and from 81 to 93 ml · min−1 · 1.48 m−2, respectively, in spite of a fall in renal perfusion pressure. Manidipine reduced the filtration fraction from 0.260 to 0.243, suggesting a preferential reduction in efferent arteriolar resistance. The fractional excretion of sodium and potassium did not change. Manidipine did not produce any significant alteration in plasma renin activity or in the plasma aldosterone concentration. The results indicate that manidipine has favourable renal effects and a concomitant hypotensive action in patients with mild-to-moderate essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265948
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  • 3
    Electronic Resource
    Electronic Resource
    EFFECTS OF HYPERINSULINAEMIA ON RENAL FUNCTION AND THE PRESSOR SYSTEM IN INSULIN-RESISTANT OBESE ADOLESCENTS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In the present study, using the euglycaemic hyperinsulinaemic glucose clamp technique, we investigated the effects of hyperinsulinaemia on sodium-water metabolism and the pressor system in obesity, both of which have been reported to be closely associated with insulin resistance and/or hyperinsulinaemia.2. Sixteen obese young subjects and 24 non-obese young subjects who were all normotensives, participated in this study. The 2h euglycaemic hyperinsulinaemic glucose clamp was performed in a fasting state. The mean glucose infusion rate needed to maintain a fasting blood sugar level (FBS) during the last 30 min of the clamp was used as an indicator of insulin sensitivity (M-value). Before and after the clamp, the following parameters were measured: creatinine clearance (Ccr); urinary excretion of sodium (UNaV); fractional excretion of sodium (FENa); plasma renin activity (PRA); plasma aldosterone concentration (PAC) and plasma noradrenaline concentration (PNA).3. The M-value was significantly lower in obese subjects compared with non-obese subjects, although FBS and fasting immunoreactive insulin levels were similar in both groups. UNaV and FENa fell only in obese subjects during the clamp, while Ccr showed no significant change in either group. PNA and PRA increased significantly and PAC tended to increase in both groups.4. These results suggest that obese subjects have insulin resistance with respect to glucose metabolism, but that urinary sodium excretion and the pressor system remain insulin-sensitive; the sensitivity of the sodium retaining action to hyperinsulinaemia was actually higher in obese subjects than in non-obese subjects. Therefore, if compensatory endogenous hyperinsulinaemia was raised by insulin resistance, these two factors may lead to chronic sodium retention and pressor system stimulation and, in turn, to hypertension in obesity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02825.x
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  • 4
    Electronic Resource
    Electronic Resource
    Preparation of optically active peralkyldiphosphines and their use, as the rhodium(I) complex, in the asymmetric catalytic hydrogenation of ketones
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 370 (1989), S. 203-221 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-328X(89)87285-7
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  • 5
    Electronic Resource
    Electronic Resource
    Mutational specificity of the umuC mediated mutagenesis in Eschericha coli
    Amsterdam : Elsevier
    Biochimie 64 (1982), S. 731-733 
    Details
    ISSN: 0300-9084
    Keywords: SOS mutagenesis ; [abr] (oh)^4Cyd; N^4-hydroxycytidine ; [abr] EMS; ethyl methanesulfonate ; [abr] ENU; ethylnitrosourea ; [abr] MMS; methyl methanesulfonate ; [abr] MNNG; N-methyl-N'-nitro-N-nitrosoguanidine ; [abr] MNU; methylnitrosourea ; [abr] UV; ultraviolet light, 4NQO 4-nitro-quinoline-N-oxide ; gene umuC ; mutagenese SOS ; mutational specificity ; specificite de mutation ; umuC gene
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0300-9084(82)80119-3
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  • 6
    Electronic Resource
    Electronic Resource
    umuC-Mediated misrepair mutagenesis in Escherichia coli: extent and specificity of SOS mutagenesis
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 111 (1983), S. 51-59 
    Details
    ISSN: 0027-5107
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0027-5107(83)90007-6
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  • 7
    Electronic Resource
    Electronic Resource
    High-resolution studies in patients with aniridia-Wilms tumor association, Wilms tumor or related congenital abnormalities (1984)
    Springer
    Human genetics 〈Berlin〉 67 (1984), S. 245-248 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We attempted to determine wheter all cases of AWTA (anirida-Wilms tumor association) or any of the following groups of patients show 11p deletion: cases of Wilms tumor with congenital abnormalities other than aniridia, those without any congenital abnormalities, tumor itself in cases of Wilsm tumor without constitutional 11p deletion and cases of aniridia or hemihypertrophy without Wilms tumor. We studied a total of 29 index patients including five cases of AWTA, four cases of Wilms tumor with various congenital abnormalities, 16 cases of Wilms tumor without other abnormalities, three cases of aniridia in one of which Wilms tumor developed later and a case of hemihypertrophy. In all five cases of AWTA and in a case of aniridia who later developed Wilms tumor, 11p deletion involving the p13 band was detected. The mother of the latter also showed an identical 11p deletion. The common segment of deletion was the middle part of the p13. Two possible hypotheses on the mechanism through which Wilms tumor might develop were evaluated, based on the distribution of break points. All other cases, including five with tumor culture, showed a normal karyotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291349
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  • 8
    Electronic Resource
    Electronic Resource
    Chloralose/ketamine anaesthesia preserves a form of postprandial sodium chloride balance in Wistar rats (1996)
    Springer
    Pflügers Archiv 432 (1996), S. 944-947 
    Details
    ISSN: 1432-2013
    Keywords: Key words Anaesthesia ; Chloralose ; Ketamine ; Sodium excretion ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Studies on the mechanisms underlying Na balance in anaesthetized rats are complicated by the fact that the most frequently used barbiturate anaesthetics attenuate or abolish this phenomenon. In the present study we show that a combination of nonbarbiturate anaesthetics: chloralose (140 mg/kg i.v.) and ketamine (30 mg/kg i.m.), preserve the ability of rats to excrete intragastrically applied NaCl loads dose dependently. Thus rats anaesthetized with this regime excreted 86–102% of in- tragastrically applied NaCl whereas rats anaesthetiz- ed with thiobutabarbitone sodium (Inactin) excreted only 20–28%. We conclude that chloralose/ketamine anaesthesia is suitable for studies on Na balance mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050220
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