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Digitale Medien

Oxygenation capabilities of basket-type bioreactors for microcarrier cultures of anchorage-dependent cells (1997)

Kalogerakis, N. ; Behie, L. A.

Springer

Bioprocess engineering 17 (1997), S. 151-156

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Details

ISSN: 0178-515X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Abstract The oxygenation capabilities of a new generation three phase – two region 1200 l bioreactor employed for the cultivation of anchorage dependent animal cells were investigated experimentally. A mathematical model has also been developed that explains qualitatively the observed oxygenation characteristics. This type of bioreactor, that uses microcarrier support particles, has two distinct mesh-separated regions so that the air bubbles in the oxygenation region do not come into contact with the microcarriers in the cell (bubble-free) region. Implications on achievable maximum cell densities are also discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004490050369

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