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Cimetidine impairs the elimination of chlormethiazole (1981)

Shaw, G. ; Bury, R. W. ; Mashford, M. L. ; [et al.]

Springer

European journal of clinical pharmacology 21 (1981), S. 83-85

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ISSN: 1432-1041

Keywords: cimetidine ; chlormethiazole ; enzyme inhibition

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Cimetidine impairs the systemic clearance of a number of low extraction drugs and this study examines its effect on the oral clearance of the high extraction drug, chlormethiazole. Cimetidine (1 g/day for 7 days) caused the clearance of chlormethiazole to fall to 69% of pretreatment values. It also prolonged the elimination half-life by 60%. The findings indicate that the metabolism of chlormethiazole is inhibited by cimetidine and the co-administration of these drugs may lead to excess sedation and respiratory depression.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00609593

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