ISSN:
1432-1041
Keywords:
Intraocular pressure, Alfentanil pretreatment
;
suxamethonium, thiopentone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effects of pretreatment with alfentanil on intraocular pressure (IOP) were investigated in 40 patients undergoing ophthalmic surgery. Patients were randomly allocated to two study groups. Group 1 patients (n=20) received alfentanil 15 μg · kg−1, vecuronium 0.01 mg · kg−1, thiopentone 3-4 mg · kg−1, and suxamethonium 1 mg · kg−1 for anaesthetic induction, whereas patients in group 2 (n = 20) received vecuronium 0.01 mg · kg−1, thiopentone 3–4 mg · kg−1, and suxamethonium 1 mg · kg−1. A total of seven measurements of intraocular pressure were taken in each patient, starting before premedication and ending after extubation of the trachea. In group 2 patients, there was an increase in IOP after endotracheal incubation. In group 1 patients, a decrease in IOP occurred which was related to the decrease in arterial blood pressure. We conclude that alfentanil pretreatment can prevent the increase in IOP following suxamethonium administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02333030
