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  • 1
    Electronic Resource
    Electronic Resource
    Effect of fibroblast interferon on colony tumor growth of miscellaneous solid human tumors (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 1455-1459 
    Details
    ISSN: 1432-1440
    Keywords: Interferon ; Antiproliferative effect ; Colony tumor growth ; Solid malignant tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antiproliferative effect of fibroblast interferon (IF-β) on the colony tumor growth of 42 miscellaneous carcinomas (15 gastric, 11 breast, eight colon, five ovarian, three bronchial) and two malignant melanomas were assayed in a semisolid, double-layered agar culture system. Of the 44 evaluable experiments only four tumor specimens (three breast-, one gastric carcinoma) showed at least a 30% inhibition of colony formation due to application of interferon at concentration of 1,000 IU/ml or less. In these cases, a dose response relationship of the interferon effect was obvious. Yet, in the majority of carcinomas investigated, interferon had no antiproliferative influence on colony tumor growth and was markedly inferior to a simultaneously tested cytostatic agent (adriamycin). Our in vitro results contradict a general direct cytotoxic action of interferon on human solid carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720993
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  • 2
    Electronic Resource
    Electronic Resource
    Detection and characterization of single molecules in aqueous solution (1996)
    Springer
    Applied physics 63 (1996), S. 517-523 
    Details
    ISSN: 1432-0649
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a confocal microscope with a single-photon avalanche photodiode as detector, we studied photon bursts of single Rhodamine 6G (R6G) and Rhodamin B-zwitterion (RB) molecules in aqueous solution by excitation of the lowest excited singlet stateS 1 with a frequency-doubled titanium: sapphire laser. Multichannel scaler traces, the fluorescence autocorrelation function and fluorescence decay times determined by time-correlated single-photon counting have been measured simultaneously. The time-resolved fluorescence signals were analyzed with a maximum likelihood estimator. Fluorescence lifetime patterns in steps of 100 ps were generated by convolution with the excitation pulse. The lifetime of theS 1 state was derived from the Kullback-Leibler minimum discrimination information. We are able to demonstrate for the first time identification of two different single dye molecules via their characteristic fluorescence lifetimes of 1.79 ± 0.33 ns (RB) and 3.79 ± 0.38 ns (R6G) in aqueous solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01828950
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  • 3
    Electronic Resource
    Electronic Resource
    Laser spectroscopy for studying chemical processes (1988)
    Springer
    Applied physics 46 (1988), S. 221-236 
    Details
    ISSN: 1432-0649
    Keywords: 82.20 ; 82.30 ; 82.80 ; 87
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In recent years, various methods have been developed to observe and to influence the course of chemical reactions using laser radiation. By selectively increasing the translational, rotational, and vibrational energies and by controlling the relative orientation of the reaction partners with tunable infrared and UV lasers, direct insight can be gained into the molecular course of the breaking and re-forming of chemical bonds. As exmaples for the application of lasers in chemical synthesis the production of monomers and catalysts is discussed. The application of linear and nonlinear laser spectroscopic methods, such as laser-induced fluorescence (LIF), Coherent anti-Stokes Raman Scattering (CARS), infrared-absorption measurements with tunable diode and molecular lasers is described for non-intrusive observation of the interaction of transport processes with chemical reactions used in industrial processes with high temporal, spectral and spatial resolution. Finally the application of a UV laser microbeam apparatus in genetic engineering for laser-induced cell fusion, genetic transformation of plant cells as well as diagnosis of human diseases by laser-microdissection of chromosomes is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692881
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  • 4
    Electronic Resource
    Electronic Resource
    Rotational distribution of nascent OH radicals after H2O2 photolysis at 193 nm (1987)
    Springer
    Applied physics 42 (1987), S. 173-179 
    Details
    ISSN: 1432-0649
    Keywords: 82.50 ; 33.50 ; 06.50
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The rotational distribution of OH(X 2Π,v″=0) radicals was investigated by resonant laser-induced fluorescence (LIF) after photolysis of H2O2 at 193 nm. A microcomputer equipped LIF arrangement allowed special shot-by-shot normalization of the fluorescence signal for noise reduction. Using a least-squares procedure we were able to account for all measured line intensities including overlapping lines (blends) and obtain a complete rotational state distribution of the OH(X 2Π,v″=0) state. The rotational excitation shows a Gaussian-like distribution with a maximum atK″=12 and with 16% of the total available energy (17,400 cm−1) appearing in rotation. Only 1% of the available energy is converted into vibration, leaving over 83% for translational excitation. The measured rotational distribution appears to fit a semiclassical theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693881
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental study of laser-induced thermal ignition in O2/O3 mixtures (1985)
    Springer
    Applied physics 37 (1985), S. 189-195 
    Details
    ISSN: 1432-0649
    Keywords: 82.50 ; 42.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract O2/O3 mixtures are ignited by absorption of laser pulses of a TEA CO2 laser along the axis of a cylindrical cell. The dependence of the radial propagation of the O3 decomposition, detected by uv absorption of the ozone, on laser fluence and on O3 concentration is investigated. Oscillations of the signals are identified to be the first radial acoustic mode of the cell. For mixtures of 0.35 bar and 0.70 bar total pressure and O3 percentages within 20–50%, the ignition limit is in the order of 0.1–0.2 J/cm3 (absorbed energy density). These values are in reasonable agreement with the results of the corresponding numerical simulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692940
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of thiopentone/suxamethonium on intraocular pressure after pretreatment with alfentanil (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 311-313 
    Details
    ISSN: 1432-1041
    Keywords: Intraocular pressure, Alfentanil pretreatment ; suxamethonium, thiopentone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of pretreatment with alfentanil on intraocular pressure (IOP) were investigated in 40 patients undergoing ophthalmic surgery. Patients were randomly allocated to two study groups. Group 1 patients (n=20) received alfentanil 15 μg · kg−1, vecuronium 0.01 mg · kg−1, thiopentone 3-4 mg · kg−1, and suxamethonium 1 mg · kg−1 for anaesthetic induction, whereas patients in group 2 (n = 20) received vecuronium 0.01 mg · kg−1, thiopentone 3–4 mg · kg−1, and suxamethonium 1 mg · kg−1. A total of seven measurements of intraocular pressure were taken in each patient, starting before premedication and ending after extubation of the trachea. In group 2 patients, there was an increase in IOP after endotracheal incubation. In group 1 patients, a decrease in IOP occurred which was related to the decrease in arterial blood pressure. We conclude that alfentanil pretreatment can prevent the increase in IOP following suxamethonium administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333030
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental determination of total reactive cross sections for H+D2(v=0)→HD+D at Ec.m.=2.11 and 1.54 eV (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 3047-3048 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452752
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  • 8
    Electronic Resource
    Electronic Resource
    Chemical reactions and lasers: Elementary steps and complex systems
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 46 (1990), S. 567-575 
    Details
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0584-8539(90)80172-U
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  • 9
    Electronic Resource
    Electronic Resource
    Improved photosynthesis of previtamin D by wavelengths of 280-300 nm
    Amsterdam : Elsevier
    Journal of Photochemistry and Photobiology A: Chemistry 61 (1991), S. 15-26 
    Details
    ISSN: 1010-6030
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1010-6030(91)85070-W
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  • 10
    Electronic Resource
    Electronic Resource
    Picosecond fluorescence lifetime measurement of the OH radical in an atmospheric pressure flame
    Amsterdam : Elsevier
    Chemical Physics Letters 142 (1987), S. 15-18 
    Details
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-2614(87)87242-1
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