ISSN:
1432-1041
Keywords:
Key words Mannitol
;
Cerebrospinal fluid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: The rise of intracranial pressure above the pre-treatment level (rebound phenomenon) is considered, in part, a consequence of osmotherapeutics penetrating into the intracranial compartments. Methods: The kinetics of mannitol in the ventricular CSF were studied in 10 patients with cerebrovascular stroke after a single i.v. infusion of 37.5 g over 15 min. Results: Maximum mannitol CSF concentrations (mean = 51.1 mg · l−1) were reached 2–12 h after termination of the infusion. Mean t1/2CSF (18.3 h) by far exceeded t1/2S (3.71 h). AUCCSF/AUCS, as a measure of mannitol CSF penetration, ranged from 0.037 to 0.390. Conclusion: The slow elimination of mannitol from CSF implies a high risk of accumulation in the central nervous compartments after repeated dosing.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050375
