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Fatal complications after myelography with meglumine diatrizoate (1990)

Hilz, M. J. ; Huk, W. ; Schellmann, B. ; [et al.]

Springer

Neuroradiology 32 (1990), S. 70-73

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ISSN: 1432-1920

Keywords: Intrathecal diatrizoate meglumine ; Lethal dysregulation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00593948

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