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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 2 (1963), S. 482-490 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Röntgenbestrahlung des Rattenkopfes hatte im Gehirn die Anhäufung von histochemisch nachweisbaren PAS-positiven Granula zur Folge, die sich als Glykogen erwiesen. Die Glykogen-Granula fanden sich hauptsächlich in Gliazellen; sie traten nicht in Nervenzellen auf. Die Anzahl der Glykogen-Granula war ungefähr proportional der verabreichten Strahlendosis. Obgleich das Vorkommen derartiger Veränderungen unter den Bedingungen von ionisierenden Teilchenbestrahlungen bekannt ist, stellt dies den ersten Nachweis nach Röntgenbestrahlung dar. Quantitative chemische Analysen des Gehirnes mittels der Glucose-Oxydase-Methode zeigten — 24 Std nach Applikation von 3.000 r — einen Anstieg des Glykogengehaltes um ca. 40%.
    Notes: Summary X-irradiation of the head of rats resulted in the accumulation of histochemically demonstrable PAS-positive granules in the brain, which were identified as glucogen. The glycogen granules were confined predominantly to the neuroglial cells; they did not appear in neurons. The amount of glycogen granules was approximately proportional to the dose administered. Although such changes are known to occur under conditions of ionizing particle radiation, this is the first demonstration that they appear following X-irradiation. Quantitative chemical analysis of the brains by the glucose oxydase method demonstrated an increase of glycogen of approximately 40%, 24 hours after exposure to 3.000 r. The biochemical change responsible for the glycogen accumulation may consist in an impairment of the enzymes mediating the incorporation and release of glucose from glycogen.
    Type of Medium: Electronic Resource
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