ISSN:
1432-0533
Keywords:
Amyotrophic lateral sclerosis
;
Anterolateral funiculus
;
Lateral corticospinal tract
;
Myelinated fiber
;
Morphometry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We carried out a morphometric study on the myelinated fibers in the anterolateral funiculus (ALF) and lateral corticospinal tract (LCS) in the cervical segment of the spinal cord of 13 patients with classic amyotrophic lateral sclerosis (ALS), 6 of whom had been on a respirator: 5 age-matched subjects were used as controls. The results obtained revealed that: (1) the fiber-size distributions of the myelinated fibers in the ALF and LCS of the control subjects had peaks at 2 μm; (2) there were marked and significant losses of large myelinated fibers in the ALF and LCS of ALS patients; (3) the patients who required respirator support showed more severe degeneration in the ALF than those who required none; and (4) the degree of myelinated fiber loss in the LCS did not correlate with either the illness duration or the history of respirator use.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296504
