ISSN:
1432-069X
Keywords:
Hair bulb papilla cells
;
Hair root sheath fibroblasts
;
Proliferation in vitro
;
DNA flow cytometry
;
Effect of different pharmacological agents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Comparative studies on growth kinetics of cultivated human hair bulb papilla cells (PCs) and hair root sheath fibroblasts (RSFs) yielded evidence of some pecularities of PCs in both proliferative behavior and morphological growth pattern. As the dermal papilla, essentially supporting the nutrition of matrix epithelium, can be considered a target tissue for agents influencing maintenance of hair growth, we studied the effects of epidermal growth factor (EGF), fibroblasts growth factor (FGF), minoxidil (Mino), and hydrocortisone (HC) on the proliferation of PCs and RSFs, both gained from dissected hair follicles of scalp biopsy specimens of two male adults and separately cultured in vitro. EGF and FGF proved to increase proliferation of both PCs and RSFs most, yet at a different intensity for each cell group. HC slowed proliferation, and Mino failed to influence growth of PCs and RSFs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417323
