ISSN:
1432-0886
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The study of RNA pol II-mediated transcription regulation has been dominated by molecular biological approaches. Although these methods continue to provide important insights, other approaches are required to insure against an oversimplified view of gene expression. Improvements in EM methods and the development of the confocal light microscope have provided alternative and complementary means of investigating gene regulation. Information on the “context” in which cis-and trans-acting factors operate can be achieved with these techniques. As a result, the spatial compartmentalization of nuclear processes involved in transcriptional and post-transcriptional processing has received considerable attention.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00355315
