ISSN:
1432-2307
Keywords:
Mitochondrial cardiomyopathy
;
Ultrastructure
;
Cytochromec oxidase deficiency
;
Ventricular tachycardia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 30-year-old woman presented with lifethreatening ventricular tachycardia without overt heart disease. Ultrastructural investigation of endomyocardial biopsy disclosed abnormally structured and often enlarged mitochondria. Morphometry revealed the ratio of volume density of mitochondria to myofibrils to be markedly increased to 0.667 as compared with five controls (mean: 0.46; range: 0.445–0.479). Investigation of mitochondrial respiratory chain enzymes revealed a 90% reduction in activity of cytochromec oxidase. Our data suggest that mitochondrial cardiomyopathy may induce malignant ventricular arrhythmias.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01600154