ISSN:
1432-1076
Keywords:
Key words Homocystinuria
;
Excitotoxicity
;
Organotypic cultures
;
Xenopus oocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The excitotoxic action of homocysteine and related sulphur-containing metabolites was investigated in organotpyic cultures derived from rat brain cortex and hippocampus by inhibition experiments using antagonists selective for different glutamate receptor subtypes. In addition the direct interaction of these metabolites with glutamate receptors expressed in frog oocytes was tested by conventional two electrode voltage clamp techniques. Conclusion Neurodegeneration and epilepsy observed in homocystinuria may be mediated by l-homocysteic and l-homocysteine sulphinic acid. Both metabolites exhibit excitotoxic potency by interaction with different glutamate receptor subtypes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00014291