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An informative polymorphism detectable by polymerase chain reaction at the 3′ end of the dystrophin gene (1990)

Oudet, C. ; Heilig, R. ; Mandel, J. L.

Springer

Human genetics 〈Berlin〉 84 (1990), S. 283-285

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ISSN: 1432-1203

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary A fragment that contains a (CA)n sequence from the 3′ untranslated region of the dystrophin gene can be amplified by the polymerase chain reaction and shows length polymorphism in a Caucasian population. The two common alleles differ by 4bp. This new genetic marker has a heterozygosity of about 35% and is typed more rapidly than a conventional restriction fragment length polymorphism. Its localisation at the 3′ end of the dystrophin gene makes it a useful tool for diagnostic applications in families with Duchenne/ Becker muscular dystrophy, and for the analysis of intragenic recombination.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00200576

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