ISSN:
1435-1463
Keywords:
Dopamine agonist
;
prolactin
;
dopamine receptor
;
5-HT agonist
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino] tetralin) is a novel aminotetralin derivative which has been proposed to be a serotonin (5-HT) agonist devoid of dopamine agonist effects. We now report that the administration of 8-OH-DPAT, like known 5-HT agonists, produced a rapid elevation of serum prolactin concentrations in male rats. The prolactin response to 8-OH-DPAT, like that induced by other 5-HT agonists, was greatly potentiated in animals pretreated with the tryptophan hydroxylase inhibitor, para-chlorophenylalanine. However, the 8-OH-DPAT-induced elevation of serum prolactin cocentrations in untreated rats was not dose-dependent and was modest in magnitude compared to that produced by known 5-HT agonists. In contrast to the stimulatory effects of 8-OH-DPAT on prolactin secretionin vivo 8-OH-DPAT suppressed the secretion of prolactin from anterior pituitary tissuein vitro, and this effect was blocked by haloperidol. The results of the present study are supportive of the view that 8-OH-DPAT has dopamine agonist, as well as 5-HT agonist, properties.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01255412
