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Digitale Medien

Skin pigmentation associated with minocycline therapy (1989)

OKADA, N. ; MORIYA, K. ; NISHIDA, K. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

British journal of dermatology 121 (1989), S. 0

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Details

ISSN: 1365-2133

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: A patient on long-term minocycline therapy developed blue-black discoloration on the legs. Skin biopsy specimens from the pigmented areas were examined by light and electron microscopy and energy-dispersive X-ray microanalysis. Pigmented granules were present at all levels of the dermis and subcutaneous fat tissues. Ultrastructural examination showed electron-dense graular material within the cytoplasm of dermal macrophages and energy-dispersive X-ray microanalysis indicated that the granules contained iron. Thyroid tissue obtained by aspiration biopsy showed the presence of fine brown granules within the cytoplasm of the follicular epithelial cells. An extract of skin from the pigmented areas was subjected to high performance liquid chromatography and minocycline was detected.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb01807.x

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