ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
There is no evidence for genetic control of the antibody response to the d-amino acid polypeptide poly(dGlu52dLys33dTyr15) in contrast to the case of the l-isomer in which the antibody response is genetically controlled and linked to the major histocompatibility locus. There is also no crossreactivity between the l- and d-isomers of the polypeptide in the induction of the immune response. Aggregation of the l-isomer with methylated bovine serum albumin (MeBSA) abolished the pattern of genetic control by increasing antibody formation in the low responders and by decreasing it in the high responders. Aggregation of the d-isomer increased rather uniformly the antibody responses of all strains, except the moderately responding WF strain. The antibody response to the MeBSA in the aggregates was uniformly low, although there was a strain dependent variation in the antibody response to MeBSA alone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1974.tb00316.x
