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EFFECTS OF LIDOCAINE ON RABBIT BRAIN MICROTUBULAR PROTEIN (1974)

Haschke, R. H. ; Byers, Margaret R. ; Fink, B. Raymond

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 22 (1974), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Microtubule repolymerization from a crude supernatant fraction prepared from rabbit brain was followed quantitatively by viscometry and electron microscopy. Lidocaine inhibits this repolymerization in a dose-dependent fashion and the effect is completely reversible upon removal of the lidocaine by dialysis. Direct counting of microtubules by electron microscopy indicates that the local anesthetic decreases the number of tubules without significantly affecting their length. An association constant of lidocaine for tubulin is estimated at 7.5 mm. Procaine and etidocaine were also found to affect the polymerization of microtubules with results similar to those found with lidocaine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04302.x

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