ISSN:
1365-2036
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In vitroω-3-fatty acids (Eicosapen) are bacteriostatic to Helicobacter pylori and have a variety of immuno-modulating effects.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To investigate the efficacy and tolerability of eicosapen (E) as an antibiotic-sparing component of a triple H. pylori eradication regimen in non-ulcer dyspepsia patients in a randomized, double-blind trial.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Non-ulcer dyspepsia patients (n=199), with a normal upper endoscopy and a positive 13C-urea breath test (UBT) were randomly assigned to either pantoprazole, clarithromycin and metronidazole (PCM) or pantoprazole, clarithromycin and eicosapen (PCE) for 7 days. Four weeks after treatment, H. pylori eradication was determined by UBT. Symptoms were followed up to 16 months.〈section xml:id="abs1-4"〉〈title type="main"〉Results:In the intention-to-treat population, PCM eradicated infection in 78% but PCE was successful in only 34% (P 〈 0.001). Symptomatic improvement occurred in both groups, and was not related to H. pylori eradication.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Eicosapen is unlikely to be useful in H. pylori eradication regimens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1365-2036.2001.00989.x
