ISSN:
1574-695X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Infection with Helicobacter pylori strains harboring determinants of pathogenicity may lead to a strong inflammatory response in gastric mucosa. In this work, we examined the frequency of the cag A, vac A and ice A genotypes in H. pylori strains isolated from Brazilian patients and correlated these with the clinical manifestations. H. pylori was isolated from 165 patients [30 with non-ulcer dyspepsia cases (NUD); 93 peptic ulcer disease (PUD): 31 gastric ulcers (GU) and 62 duodenal ulcer disease (DU); 18 with erosive gastritis (EG); and 24 gastroesophageal reflux disease (GERD)]. Allelic variants of cag A, vac A and ice A were identified using the polymerase chain reaction. More than one H. pylori strain was detected in 28 cases (17%), and these were excluded from the statistical analysis. We were unable to confirm an association between ice A status and clinical outcome. There was a strong association between the genotype cag A-positive vac A s1 and PUD. However, logistic regression analysis showed that vac A s1 was the only predictive factor for PUD (OR=4.19; 95% CI 1.95–8.98). The presence of the less virulent strain vac A s2 was related to GERD (OR=8.59; 95% CI 2.85–25.91). Our results support the hypothesis that virulent strains may protect against the development of GERD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1016/S0928-8244(03)00029-4
