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Digitale Medien

The effects of proglumide on morphine induced motility changes (1984)

Ben-Horin, Nitsan ; Ben-Horin, Einat ; Frenk, Hanan

Springer

Psychopharmacology 84 (1984), S. 541-543

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Details

ISSN: 1432-2072

Schlagwort(e): Morphine ; Cholecystokinin ; Proglumide ; Locomotion ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Proglumide (0.02 mg/kg), a cholecystokinin antagonist, was administered to rats either together with or without morphine (0, 5, 15, or 45 mg/kg). Whereas proglumide in the absence of morphine showed a trend towards enhanced behavioral activation, it potentiated the hy[okinesia induced by morphine. These results are consistent with the hypothesis that endogenous cholecystokinin tonically antagonizes opiate modulation of motility, irrespective of whether such modulation is produced by opiates and endogenous or exogenous origin.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00431463

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