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Digitale Medien

The pharmacokinetics of ofloxacin in healthy adult male volunteers (1987)

Leroy, A. ; Borsa, F. ; Humbert, G. ; [weitere]

Springer

European journal of clinical pharmacology 31 (1987), S. 629-630

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Details

ISSN: 1432-1041

Schlagwort(e): ofloxacin ; pharmacokinetics ; healthy male volunteers

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Conclusion In healthy subjects ofloxacin pharmacokinetics were found to be linear in the dose range studied (100–400 mg). The terminal half-time was 7.5–8 h and plasma ofloxacin concentrations were still detectable at 16 and 24 h after administration. The ratio of renal ofloxacin clerance: creatinine clearance was 1.35–1.82 and was not significantly different for the three doses. The non-renal clearance of ofloxacin was 40–60 ml·min−1, i.e. 20–30% of the total body clearance. Food intake delayed the absorption of ofloxacin but did not significantly modify its elimination.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00606645

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