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Digitale Medien

Phase II study of VP 16-213 (etoposide) in metastatic transitional cell urothelial cancer (1984)

Ponder, B. A. J. ; Oliver, R. T. D.

Springer

Cancer chemotherapy and pharmacology 12 (1984), S. 64-65

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Details

ISSN: 1432-0843

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Fifteen patients with measurable metastatic transitional cell bladder cancer were treated with VP 16-213 100 mg/m2 IV daily for 4 days, repeated every 3 weeks. There were no complete or partial (greater than 50% reduction in area, maintained for 6 weeks) responses. Two patients showed transient reduction by 50% in the area of measurable lesions, and a further five patients showed brief stabilisation of previously progressive disease. The treatment was well tolerated. In two patients, total WBC at the nadir fell below 1.0×109/l but without complications from infection. We conclude that VP 16-213 is inactive in metastatic transitional cell urothelial cancer.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00255913

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