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Digitale Medien

Asparagine as Precursor for Transmitter Aspartate in Corticostriatal Fibres (1980)

Reubi, J. C. ; Toggenburger, G. ; Cuénod, M.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 35 (1980), S. 0

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Details

ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: The role of asparagine as precursor for the neurotransmitter aspartate was investigated in rat striatum in vitro.14C-asparagine incubated with striatal slices is converted to a great extent to 14C-aspartate which is released in a calcium-dependent manner by high KCl. Furthermore, a frontoparietal cortex ablation of two weeks produces a decrease of more than 70% in the striatal release of newly synthetized 14C-aspartate, whereas the striatal GABA release is unaffected. This suggests that asparagine is a possible pre-cursor in vitro for transmitter aspartate in the striatum. This reaction is dependent on intact corticostriatal fibres.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb07103.x

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