Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
35 (1980), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The role of asparagine as precursor for the neurotransmitter aspartate was investigated in rat striatum in vitro.14C-asparagine incubated with striatal slices is converted to a great extent to 14C-aspartate which is released in a calcium-dependent manner by high KCl. Furthermore, a frontoparietal cortex ablation of two weeks produces a decrease of more than 70% in the striatal release of newly synthetized 14C-aspartate, whereas the striatal GABA release is unaffected. This suggests that asparagine is a possible pre-cursor in vitro for transmitter aspartate in the striatum. This reaction is dependent on intact corticostriatal fibres.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1980.tb07103.x
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