ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Another promising application area for tandem mass spectrometry is targeted class analysis. Particularly favorable examples of this are analyses for penicillins and other β-lactams, important compound classes sought in complex mixtures. Electron ionization of these compounds produces a major fragment ion by lactam ring cleavage; collisionally activated dissociation of this ion yields spectra characteristic of the compound class. Four isomeric [C7H12NO2S]+ ions and two homologous ions illustrate these points. Their collisionally activated dissociation spectra, like the corresponding molecular electron ionization spectra, show fragmentations characteristic of the β-lactam ring size and of substituent type and position, but not of stereochemistry.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200100404
