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Digitale Medien

Electron impact mass spectrometry of substituted 1,3,8-triazaspiro[4,5]decan-4-ones (1989)

Danieli, Bruno ; Rubino, Federico Maria ; Zecca, Luigi

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 18 (1989), S. 1000-1004

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Details

ISSN: 0887-6134

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The neuroleptic butyrophenone drug spiroperidol (8-[4-fluorophenyl)-(4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one) and related compounds are valuable tools for mapping the dopamine receptors in the brain. During the development of the radiochemical synthesis of these compounds with very short-lived isotopes suitable for positron emission tomography studies, positive electron impact mass spectrometric information was obtained. Ion series are present in the spectra of all 12 compounds studied, which unambiguously allow recognition of type and site of substitution on the spiro system.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200181108

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