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Electronic Resource

Current Concepts in Intestinal Peptide Absorption (1996)

Fricker, Gert ; Drewe, Jürgen

New York, NY [u.a.] : Wiley-Blackwell

Journal of Peptide Science 2 (1996), S. 195-211

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ISSN: 1075-2617

Keywords: peptide absorption ; dipeptide carrier ; brush border membrane ; M-cell, Caco-2 cell ; Chemistry ; Biochemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Today there is considerable interest in oral peptide delivery. However, oral administration of peptides is limited by a low bioavailability and a high variability in plasma levels. A review is given of the literature describing the major barriers in peptide absorption, the basic mechanisms of intestinal peptide transport, the experimental models and the pharmaceutical approaches currently used in the investigation of peptide and protein absorption processes.

Additional Material: 4 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/psc.66

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