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Digitale Medien

Study of biological activity regenerated by the oxidation of fully reduced insulin (1966)

Pruitt, Kenneth M. ; Robison, Bonnie S. ; Gibbs, Julian H.

New York : Wiley-Blackwell

Biopolymers 4 (1966), S. 351-364

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Details

ISSN: 0006-3525

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Various techniques for recombining the fully reduced A and H chains of insulin were studied. Best results were obtained from water solutions of the reduced chains allowed to oxidize by standing in air at 3 °C. and from metal-catalyzed oxidation under the same conditions but in 7.6M urea solutions. Average net regeneration of insulin was 6% by weight, based on rat hemidiaphragm analysis for insulin activity. The theoretical yield for a random recombination of the A and B chains was calculated to be 3%. The 50% yield of insulin (from the oxidation of reduced insulin thiosulfate) reported by Jiang et al. could not. be confirmed.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bip.1966.360040308

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