ISSN:
0002-9106
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
CFl female mice were time mated and the embryos at each gestation day from 0.0 to 18.0 were x-rayed to 100 r and the young carried to four months at which time a skeletal study was made. With this exposure the litters were reduced in size, following irradiation at certain gestation ages, and there was neo-natal mortality so that this skeletal study is based upon the survivors to four months and represents the maximum development under the conditions of irradiation. The sex ratio was not altered by this irradiation. Male mice of this strain are always heavier than the females of the same age, and this exposure reduced the over-all average of either sex by 2.5 grams. The skeletal measurements were taken from 1,005 radiographs of the living animals, and the averages calculated for each gestation day. There were sex differences in stunting, even when x-irradiation occurred before day 9.0. When the differences were pronounced the female was the more adversely affected. The highest statistical significance in skeletal effects of seven measurements was between 11 and 13 days, when the embryo shows the earliest skeletal differentiation. Such mice were topographically well developed.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aja.1001150111
