ISSN:
0003-276X
Schlagwort(e):
Life and Medical Sciences
;
Cell & Developmental Biology
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Medizin
Notizen:
A radioimmunoassay for insulin, together with ultrastructural observations of the endocrine pancreas, were utilized to investigate developmental aspects of insulin storage and secretion in the chick embryo. Immunoreactive insulin was detected from the fifth embryonic day onwards, in both the pancreas and blood plasma. In addition, margination of well-developed beta granules, and emiocytotic events were observed as early as the fifth embryonic day. The initial appearance of insulin, together with its subsequent developmental profile, correlate well with major metabolic events occurring in the embryonic chick, and are discussed in relation to a functionally responding system, the developing liver. The present data show that the chick endocrine pancreas has the potential for activity very early in development, and that insulin may be secreted at earlier embryonic stages than hitherto accepted.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/ar.1091800308