ISSN:
0941-1216
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Robustness and Susceptibility as Descriptors for the Validation of Analytical SystemsThe use and meaning of robustness and similar terms well known but not defined in quality control and validation are discussed. Susceptibility is recommended as a numerical descriptor. Since limited errors of analytical signals can be tolerated and small deviations of method variables cannot be avoided susceptibility is defined as Ai,j=ΔSi,max/ΔVj, the maximum variation Δ of the analytical signal Si caused by a variation Δ of the system variable j on its level Vj. The need of rational discussion of and consensus on tolerable variations Δ is stressed.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19943360408
