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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 336 (1994), S. 525-529 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis of ten new thyrotropin-releasing hormone analogues (15-24) which contain uncoded amino acids (L- and D-homoleucine, L- and D-homophenylalanine, L-homoproline and 6-ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N-protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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