ISSN:
0268-2605
Keywords:
Diorganotin
;
xanthates X-ray
;
antitumour
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A series of diorganotin bisxanthate compounds, [R2Sn(S2COR′)2] (R=Me, Et, nBu, tBu, and Ph; R′=Et, iPr and cHex) have been prepared and characterized by spectroscopic methods (IR, NMR and FAB MS). The xanthate ligands chelate the R2Sn moieties forming disparate Sn-S bonds leading to skew-trapezoidal biypramidal tin atom geometries. The crystal structure of a representative compound, [Ph2Sn(S2COEt)2], confirms the spectroscopic results and shows the tin atom to be coordinated by two asymmetrically chelating xanthate ligands [Sn-S(1) 2.486(1), Sn-S(2) 3.052(1) Å and Sn-S(3) 2.484(1), Sn-S(4) 3.220(1) Å] with the two phenyl substituents lying over the weaker Sn-S interactions so that C-Sn-C is 126.5(1)∘. Crystal data for [Ph2Sn(S2COEt)2]: monoclinic space group P21/n: a=9.645(1), b=23.723(3), c=9.798(2) Å, ß=100.23(1)∘, V=2206.2 Å3, Z=4; 2708 data refined to final R 0.023. A selection of these compounds has been evaluated for activity against the L1210 mouse leukaemia cell line.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590070205