ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A new class of antiphlogistic substances is described. They are 4-phenyl-1, 2-dihydrocinnolins diacylated in 1, 2-position by alkylmalonic acids. The compound which pharmacologically has been investigated most thoroughly is cinnopentazone (II). Its synthesis and behaviour towards hydrolytic and oxidative agents are described. Some relations between the chemical structure of these series of substances and their antiinflammatory activity as well as their classification as antiphlogistics according to some model reactions are discussed.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19680510813