ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Treatment of 3-oxo-4, 5-oxido steroids with lead tetraacetate results in acetoxylation in the 2α-position as could be shown by independent synthesis of the acetoxylated compounds. The products of this reaction rearrange even under very mild conditions (chromatography on silicagel or alumina) to the corresponding 2,3-dioxo-Δ4 compounds. The influence of structure and conformation of the various intermediates on their NMR.-spectra is discussed. A mechanism for this new transformation is proposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19690520213