ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
D, L-4-Oxo-homotyrosine was synthesized by the acetylaminomalonic ester pathway. The optical resolution was carried out by means of the enzyme acylase I. The L-configuration of the enzymatically produced amino acid was confirmed by degradation to L-aspartic acid.4-Oxo-homotyrosine obtained by degradation of the polypeptide antibiotic echinocandine B has D-configuration, but his optical purity is low. A hypothetical explanation for its formation from the (2 S, 3 S, 4 S)-3,4-dihydroxyhomotyrosine residue of echinocandine B is proposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19800630125