ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Four carotenoids (zeaxanthin 1, astaxanthin 2, and their C50 synthetic isoprene-homologues 3 und 4) have been incorporated into bilayer unilamellar vescles of dimyristoylphospatidylcholine as proved by coelution on a Sepharose column. The incorporation into the bilayer proper has been proved by the sensitivity to phase transition of UV/VIS spectra and circular dichroism. The UV/VIS absorptions of the carotenoids are typical of a lipidic environment. At the temperature of phase transition occur both intermolecular phenomena (aggregation of carotenoid molecules) and intramolecular changes (conformational change). The relative solubilities of the various carotenoids in this phospholipid membrane can be fitted with molecular parameters (length of the lipophilic carotenoid segment vs. lipid bilayer thickness).
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19860690104