ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of 6,7-Dihydro-2H-pyrimido[6,1-a]isoquinolin-4(3H)-ones and Analogous Compounds and their Activity as Blood-Platelet InhibitorsThe synthesis of 6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-4(3H)-ones and of analogous compounds is described. These compounds are powerful phosphodiesterase inhibitors and, therefore, inhibit blood-platelet aggregation independent of the agonist. They exhibit, too, cardiac activities. However, there is evidence for selective action. A structure-activity relationship for platelet-aggregation inhibitors is discussed.
Additional Material:
9 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19860690722