ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Two novel naphthoxirene derivatives 1 and 2 their glucosides 3 and 4 have been isolated from the root bark of Sesamum angolense Welw. (Pedaliaceae) by preparative liquid chromatography. The structure of 1 was established by X-ray diffraction analysis. The identities of the other naphthcxirenes were deduced by spectroscopic (IR, UV, 1H-NMR, 13C-NMR, EI-MS, DCI-MS) and chemical methods (oxidation, acid and enzymatic hydrolysis). Compounds 1-3 exhibited antifungal activity. Naphthoxirene 1 was, in addition, cytotoxic to human colon carcinoma cells.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19870700613