ISSN:
0018-019X
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
N-Allyl- and N-[(Cyclopropyl)methyl]-3,4-dimethoxy-5-methylmorphinan-6-one (9 and 10, resp.) were synthesized from 5-methyldih drothebainone (1). This essential intermediate was prepared from the baine via 5-methylthebaine (5) employing a novel route. The Pharmacological studies showed 9 and 10 to be potent opioid agonists. Compound 10 was found to have preference for kappa rather than mu opioid receptors.
Zusätzliches Material:
5 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hlca.19880710318