ISSN:
0020-7608
Keywords:
Computational Chemistry and Molecular Modeling
;
Atomic, Molecular and Optical Physics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
AM1 calculations have been used to study the effects of CH3+ attachment on the structures, energies, and, in some cases, proton transfer reactions of guanine cytosine base pairs. Methylation of both the guanine 3- and O6-positions is predicted to lead to chemically significant concentrations of intermediate base pairs arising from proton transfer from the guanine 1- to the cytosine 3-position. The possible biological implications of such intermediates in nucleic acids is discussed in relation to the formation of either doubly abasic sites or abasic sites opposite potentially miscoding DNA lesions. © 1992 John Wiley & Sons, Inc.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/qua.560440416
